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TLS Online TPP Program

#Question id: 14764

Match the following proteins (Column I) with their function (Column II). Which of the following is correct?

Column I

Column II

a. Profilin

i. binds to the (+) end of an actin filament, thereby inhibiting subunit addition or loss.

 

b. Cofilin

ii. blocks (−) ends, inhibits filament disassembly, to stabilize filaments

c. Thymosin-β4

iii. involved in actin treadmilling, but it binds specifically to F-actin in which the subunits contain ADP

d. Cap Z

iv. binds ADP–G-actin and catalyzes the exchange of ADP for ATP

e. Tropomodulin

v. binds to ATP–G-actin in such a way that it inhibits addition of the actin subunit to either end of the filament.

#Unit 2. Cellular Organization
  1. a-i, b-ii, c-v, d-iv, e-iii
  2. a-ii, b-v, c-iv, d-iii, e-i
  3. a-iii, b-ii, c-i, d-iv, e-v
  4. a-iv, b-iii, c-v, d-i, e-ii
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TLS Online TPP Program

#Question id: 4084

#Unit 3. Fundamental Processes

The nuclear pore complex

a. is a large complex made of many different proteins.

b. is an octagonal, membrane-embedded structure with long filaments.

c. is required for transport of all molecules in or out of the nucleus.

d. binds to importin via FG-repeats.

e. hydrolyzes bound GTP to GDP
TLS Online TPP Program

#Question id: 4085

#Unit 3. Fundamental Processes

When TAT protein fails to bind to the TAR region of the HIV transcript, which of the following statements is (are) true?
TLS Online TPP Program

#Question id: 4086

#Unit 3. Fundamental Processes

RNA interference

a. utilizes antisense RNA.  

b. utilizes double-stranded RNA.

c. is used to silence expression of genes. 

d. utilizes short interfering RNAs.
TLS Online TPP Program

#Question id: 4087

#Unit 3. Fundamental Processes

Polyadenylation can promote translation

a. of the fragile-X gene. 

b. of stored oocyte mRNAs.

c. by allowing for greater interaction at the 5´ end.

d. by allowing for greater interaction with translation initiation factors.
TLS Online TPP Program

#Question id: 4088

#Unit 3. Fundamental Processes

The 28S, 18S, and 5.8S rRNAs are

a. transcribed by RNA polymerase II.

b. encoded by a single transcription unit.

c. arranged in tandem arrays. 

d. processed in the cytoplasm.
TLS Online TPP Program

#Question id: 4089

#Unit 3. Fundamental Processes

An investigator incubates an unprocessed RNA molecule containing an intron in an extract absent of any protein. Correct splicing of the RNA is observed, but only when guanosine is present. What can the investigator conclude about the RNA molecule?

a. It contains a ribozyme. 

b. Self-splicing has occurred.

c. It contains a group II intron.

d. It contains a group I intron.