TLS Online TPP Program

#Question id: 14766


Which of the following statements does not belongs to the regulatory mechanism of the Arp2/3 complex by WASp and PI(4,5)P2?

#Unit 2. Cellular Organization
  1. The NPF WASp is inactive due to an intramolecular interaction that masks the WCA domain. 
  2. NPF WASp is activated by a coincidence detection mechanism, it must bind both the regulatory phospholipid PI(4,5)P2 though its basic domain (B) and the membrane-bound active small G protein Cdc42-GTP through its Rho-binding domain. 
  3. When activated by the Cdc42-GTP, the intramolecular interaction in WASp is relieved, allowing the W domain to bind actin and the acidic A domain to activate the Arp2/3 complex.
  4. The Arp2/3 branch makes a characteristic 70° angle between the old and new filaments.