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TLS Online TPP Program

#Question id: 1364

In mice engineered to overexpress the syndecan-1 gene in the hypothalamic region of the brain and other tissues, normal control of feeding by antisatiety peptides is disrupted, and the animals overeat and become obese. Other studies have shown that syndecan-3 may also be involved in the regulation of feeding behavior. Given the following information, which of these outcomes might you expect in experimentally manipulated mice?

I. Hypothalmic expression of syndecan-3 is increased by fasting.

II. Syndecan-3 knockout mice are resistant to diet-induced obesity.

III. Heparinase can cleave syndecan-3 to release heparin sulfate GAG chains that may suppress the activity of antisatiety peptides and feeding behavior.

Following statements are:

A. Overexpression of heparinase in mice with normal levels of syndecan-3 would result in resistance to diet-induced obesity.

B.  In mice with normal levels of syndecan-3, fasting followed by free access to a high-fat diet would lead to resistance to diet-induced obesity.

C. Lack of heparinase in mice with normal levels of syndecan-3 would result in animals that overeat and become obese.

D. Overexpression of heparinase in syndecan-3 knockout mice would reverse the resistance to diet-induced obesity.

Which of the following combination is correct?

#Unit 4. Cell Communication and Cell Signaling

  1. A and B

  2. B and C

  3. A and C

  4. C and D

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TLS Online TPP Program

#Question id: 17808

#Unit 8. Inheritance Biology

In humans, albinism (unpigmented skin, hair, and eyes) is due to an enzymatic deficiency, and it is an autosomal recessive trait. Suppose that in a small country of one million people (“Generation 1”), there are 500 aa albinos and 9000 Aa heterozygous carriers. What is the probability that a child will be albino if: One parent is a non-albino member of Generation 2, and the other parent is a non-albino member of Generation 1.
TLS Online TPP Program

#Question id: 17809

#Unit 8. Inheritance Biology

In humans, albinism (unpigmented skin, hair, and eyes) is due to an enzymatic deficiency, and it is an autosomal recessive trait. Suppose that in a small country of one million people (“Generation 1”), there are 500 aa albinos and 9000 Aa heterozygous carriers. What is the probability that a child will be albino if: Both parents are members of Generation 2, and one parent is albino and the other is non-albino.
TLS Online TPP Program

#Question id: 4900

#Unit 8. Inheritance Biology

The chlorophyll-deficient types occur in a particular plant species due to a mutation in the DNA of the chloroplast itself, Female cytoplasm chlorophyll-deficient organisms crossed with male normal chlorophyll will produce progeny
TLS Online TPP Program

#Question id: 26787

#Unit 8. Inheritance Biology

In the S phase of meiotic interphase, each chromosome replicates, producing two copies of each allele, one on each chromatid, the homologous chromosomes segregation takes place in__

Which of the following statements is correct about the segregation of chromosomes?

a.If no crossing over has taken place, the two chromatids of each chromosome segregate in anaphase II and are identical

b. If crossing over has taken place, the two chromatids are no longer identical, and the different alleles segregate in anaphase II

c. If no crossing over has taken place, the two chromatids of each chromosome segregate in anaphase I and are identical
TLS Online TPP Program

#Question id: 26788

#Unit 8. Inheritance Biology

Which of the following factors did not contribute to Mendel’s success in his study of heredity?

a.His use of the monoecious pea plant

b.His study of plant chromosome

c.His adoption of an experimental approach

d.His use of mathematics

e.The Plant use is easy to cultivate
TLS Online TPP Program

#Question id: 26789

#Unit 8. Inheritance Biology

Given below are types of crossing in column II and their associated features/effects/functions in column I

 Select the correct set of combinations from the options given below: