The transformation of a normal cell to a cancer cell is accompanied  by the loss of function of one or more tumor‐suppressor genes. High‐throughput sequencing studies have identified hundreds of genes that are implicated as tumor suppressors in humans. Some of the better characterized genes;

Gene	Primary tumor	Proposed function
i) APC	Colorectal	Binds β ‐catenin acting as transcription factor
ii) BRCA1	Breast	DNA repair
iii) MSH2, MLH1	Melanoma, pancreatic	p16: Cdk inhibitor ARF: stabilizes p53
iv) E‐Cadherin	Breast, colon	Cell adhesion molecule
v) INK4a	Colorectal	Mismatch repair
vi) NF1	Neurofibromas	Activates GTPase of Ras

Choose incorrect matching regarding tumor‐suppressor genes/primary tumor/proposed functions;

TLS Online TPP Program

#Question id: 32209

#Unit 1. Molecules and their Interaction Relevant to Biology

Identify the structure shown

TLS Online TPP Program

#Question id: 32210

#Unit 1. Molecules and their Interaction Relevant to Biology

Identify the structure shown

 

TLS Online TPP Program

#Question id: 32211

#Unit 1. Molecules and their Interaction Relevant to Biology

Identify the structure shown

 

TLS Online TPP Program

#Question id: 32212

#Unit 1. Molecules and their Interaction Relevant to Biology

Identify the structure shown

TLS Online TPP Program

#Question id: 32213

#Unit 1. Molecules and their Interaction Relevant to Biology

Identify the structure shown

 

TLS Online TPP Program

#Question id: 32214

#Unit 1. Molecules and their Interaction Relevant to Biology

Identify the structure shown