The transformation of a normal cell to a cancer cell is accompanied  by the loss of function of one or more tumor‐suppressor genes. High‐throughput sequencing studies have identified hundreds of genes that are implicated as tumor suppressors in humans. Some of the better characterized genes;

Gene	Primary tumor	Proposed function
i) APC	Colorectal	Binds β ‐catenin acting as transcription factor
ii) BRCA1	Breast	DNA repair
iii) MSH2, MLH1	Melanoma, pancreatic	p16: Cdk inhibitor ARF: stabilizes p53
iv) E‐Cadherin	Breast, colon	Cell adhesion molecule
v) INK4a	Colorectal	Mismatch repair
vi) NF1	Neurofibromas	Activates GTPase of Ras

Choose incorrect matching regarding tumor‐suppressor genes/primary tumor/proposed functions;

TLS Online TPP Program

#Question id: 28767

#Unit 2. Cellular Organization

Plant vacuole act as__

a) storage organelle for nutrients and waste products

b) degradative compartment

c) an economical way of decreasing cell size

d) a controller of turgor pressure

TLS Online TPP Program

#Question id: 28768

#Unit 2. Cellular Organization

Given following paths from different sources feed substances into lysosomes for digestion, find out the A, B and C?

TLS Online TPP Program

#Question id: 28769

#Unit 2. Cellular Organization

Autophagy occurs in the following sequence of steps___

a) Nucleation of autophagosome formation by ATG9

b) Digestion of the inner membrane and the luminal contents of the autophagosome.

c) Fusion of the autophagosome with lysosomes, catalyzed by SNAREs.

d) Induction by inhibition of mTOR complex 1

e) Closure of the membrane cup to form autophagosome

TLS Online TPP Program

#Question id: 28770

#Unit 2. Cellular Organization

Autophagy can be either;

I- Nonselective autophagy

II- Selective autophagy

a) Closure of the membrane cup to form autophagosome

b) a bulk portion of cytoplasm is sequestered in autophagosomes

c) used to destroy invading microbes

d) Nucleation of autophagosome formation by ATG1

Find out the correct match statements of about selective as well as nonselective autophagy?

TLS Online TPP Program

#Question id: 28771

#Unit 2. Cellular Organization

Which of the following sorting signal that directs lysosomal hydrolases from the TGN to the late endosome?

TLS Online TPP Program

#Question id: 28772

#Unit 2. Cellular Organization

M6P residues are generated in the cis-Golgi by which of the following Golgi-resident enzymes?

a) N-acetylglucosamine (GlcNAc) phosphotransferase

b) ornithine transcarbamylase 

c) Phosphodiesterase

d) Catalases