#Question id: 1366

Mechano-transduction is the reciprocal interconversion of a mechanical force—or stimulus—and biochemical processes. These interconversions underlie a variety of biological activities, such as signaling, regulated gene expression, cell proliferation, cell migration, and interactions among cells and between cells and the ECM. Mechano-transduction in the context of cell-cell and cell-ECM interactions usually involves a cell-surface CAM or adhesion receptor that transmits mechanical force or biochemical information across the plasma membrane and one or more intracellular or extracellular mechano-sensors that respond to the mechanical stimulus by changing shape and activity. In Hypothetical model of the partial unfolding of a fibronectin type III, when that protein is subjected to mechanical force, following observations are-

A. Mechanical force generated within the cell by actin movement and transduce via multiple integrin adhesion receptors bound to the extracellular dimeric fibronectin can partially unfold the fibronectin.

B. The unfolding is thought to expose a putative, previously hidden binding site on fibronectin that has the potential to form β sheets with other fibronectin molecules, recruiting them to form fibronectin fibrils, and thus helping assemble the ECM.

According to observations which of the following protein act as mechano-sensor and mechano-transducer respectively?