TLS Online TPP Program

#Question id: 1368


The following statements are made with reference to the characteristic of proteoglycans (major constituents of ECM). Which one of them is incorrect?

#Unit 4. Cell Communication and Cell Signaling
  1. Perlecan the major secreted proteoglycan in basal laminae, consists of a large multidomain core protein (∼470 kDa) to which polysaccharides are covalently attached.

  2. Perlecan contains three types of covalent polysaccharide chains: N-linked chains, O-linked chains, and glycosaminoglycans (GAGs).

  3. Perlecan can be found in basal laminae and in non–basal laminal ECM.

  4. The adhesion receptor dystroglycan can bind perlecan indirectly, via perlecan’s LG domains, and directly, via its binding to laminin.