Neurofibromatosis is a condition in humans which is generally inherited in a dominant fashion. Assuming this disorder is 90% penetrant, what is the chance that a single child born to a father with neurofibromatosis and a mother known not to carry the mutation will have the disorder?

TLS Online TPP Program

#Question id: 28795

#Unit 2. Cellular Organization

There are two major classes of actin-nucleating proteins:

I- Formins

II- Arp2/3 complex

a) nucleates the assembly of branched actin networks

b) landing site for profilin–ATP–G-actin

c) nucleate the assembly of unbranched filaments

Match the correct statements with ANPs-

TLS Online TPP Program

#Question id: 28796

#Unit 2. Cellular Organization

Formin family members have two adjacent domains such as;

I- FH1

II- FH2

a) form a nucleate filament assembly

b) rich in proline

c) form a dimer

d) landing site for profilin–ATP–G-actin

e) assembly of unbranched filaments

Match the correct statements with given formin family domain;

TLS Online TPP Program

#Question id: 28797

#Unit 2. Cellular Organization

Formins are activated by___

TLS Online TPP Program

#Question id: 28798

#Unit 2. Cellular Organization

To nucleate the assembly of branched actin filaments, Arp2/3 needs to be activated by___

a) Formins protein

b) nucleation promoting factor (NPF)

c) actin-nucleating proteins (ANP) 

d) Act A protein

TLS Online TPP Program

#Question id: 28799

#Unit 2. Cellular Organization

Arp2/3 needs to be activated by interacting with a nucleation promoting factor (NPF). Although there are many different NPFs, The major NPF family is characterized by the presence of a region called___

TLS Online TPP Program

#Question id: 28800

#Unit 2. Cellular Organization

Which type of signal is require to the activation of WASp, these signal input is called coincidence detection?

a) surface a protein ActA

b) regulatory phospholipid PIP2

c) small GTP-binding protein Rac1

d) small GTP-binding protein Cdc42