Following statements are regarding to cholera toxins which can affect the junction’s activity. a. Toxins produced by Vibrio cholerae, the enteric bacterium that causes cholera, alter the permeability barrier of the intestinal epithelium by altering the composition or activity of gap junctions. b. Vibrio cholerae also releases a protease that disrupts tight junctions by degrading the extracellular domain of occludin. c. Toxin-induced changes in tight-junction permeability (increased paracellular transport) and in protein-mediated ion pumping (decreased transcellular transport) can result in massive losses of internal body ions and water into the gastrointestinal tract, which in turn leads to diarrhea and potentially lethal dehydration. d. Toxin-induced changes in tight-junction permeability (decreased paracellular transport) and in protein-mediated ion pumping (increased transcellular transport) can result in massive losses of internal body ions and water into the gastrointestinal tract, which in turn leads to diarrhea and potentially lethal dehydration. Which of the following statements are correct? -triyambak.org