Following statements are regarding to gap junctions.

i. Vertebrate gap junctions are composed of connexins, a family of structurally related transmembrane proteins with molecular weights between 26,000 and 60,000.

ii. Each vertebrate hexagonal particle consists of six noncovalently associated connexin molecules. Each individual connexin molecule has two membrane-spanning α helices with a topology similar to that of claudin.

iii. The permeability of gap junctions is regulated by posttranslational modification of connexins (e.g., phosphorylation) and is sensitive to changes in environmental conditions

such as intracellular pH and Ca2+ concentration, membrane potential, and the intercellular potential between adjacent interconnected cells (“voltage gating”).

iv. The assembly of connexins, their trafficking within cells, and the formation of functional gap junctions apparently depend on N-cadherin and its associated adapter proteins as well as desmosomal proteins.

Which of the following statements are correct?

#Question id: 5369

#Unit 8. Inheritance Biology

Above family shows inheritance of colour-blindness is recessive genetic disorder. Which of the following is correct statement? (All persons are outside of family either homozygous (female) or hemizygous (Male) are consider)

#Question id: 5370

#Unit 8. Inheritance Biology

The pedigree below represents the inheritance of an X link recessive trait. The probability of effected child in fourth generation of family?

#Question id: 5371

#Unit 8. Inheritance Biology

The trait represented in the following pedigree (shaded symbols) is known to be inherited as a single dominant gene. Calculate the probability of the trait appearing in the offspring if the first cousins should marry and have children.

#Question id: 5372

#Unit 8. Inheritance Biology

Consider the following diagrams, each being a different situation in which an entire gene is represented in a higher organism. In some cases, a point mutation exists (indicated by p). In other cases, a deletion has occurred (indicated by xxxxx), both of which render the gene nonfunctional

Which of the following homozygous cross would produce wild type phenotype?

#Question id: 5373

#General Aptitude

The average of first 10 natural number is :

#Question id: 5374

#General Aptitude

The average of 11 result is 50 . if the average of first 6 result is 49 and that of last 6 results is 52,find the sixth result .