Following statements are regarding to cell-cell and cell–extracellular matrix junctions and their adhesion molecules.

A. Adherens junctions and desmosomes are integrin-containing anchoring junctions that bind the membranes of adjacent cells, giving strength and rigidity to the entire tissue.

B. Hemidesmosomes are cadherin-containing anchoring junctions that attach cells to elements of the underlying extracellular matrix.

C. Integrins are a large family of αβ heterodimeric cell-surface proteins that mediate both cell-cell and cell-matrix adhesions and inside-out and outside-in signaling in numerous tissues.

D. Tight junctions block the diffusion of proteins and some lipids in the plane of the plasma membrane, contributing to the polarity of epithelial cells. They also limit and regulate the extracellular (paracellular) flow of water and solutes from one side of the epithelium to the other.

Which of the following statements are incorrect?

TLS Online TPP Program

#Question id: 19114

#Unit 8. Inheritance Biology

You are conducting genetic linkage studies of an autosomal recessive disease whose chromosomal location has not been firmly established. You are focused on two SSR markers that may be linked to each other and to the disease. Here are two families in which some individuals are affected:

                                       

Calculate LOD scores for linkage at θ= 0.02 between the disease and SSR42 in Family 1.

TLS Online TPP Program

#Question id: 19115

#Unit 8. Inheritance Biology

You are conducting genetic linkage studies of an autosomal recessive disease whose chromosomal location has not been firmly established. You are focused on two SSR markers that may be linked to each other and to the disease. Here are two families in which some individuals are affected:

                

Calculate LOD scores for linkage at θ= 0.02 between the disease and SSR43 in Family 1.

TLS Online TPP Program

#Question id: 19116

#Unit 8. Inheritance Biology

You are conducting genetic linkage studies of an autosomal recessive disease whose chromosomal location has not been firmly established. You are focused on two SSR markers that may be linked to each other and to the disease. Here are two families in which some individuals are affected:

                             

Calculate LOD scores for linkage at θ= 0.02 between the disease and SSR42 in Family 2.

TLS Online TPP Program

#Question id: 19117

#Unit 8. Inheritance Biology

You are conducting genetic linkage studies of an autosomal recessive disease whose chromosomal location has not been firmly established. You are focused on two SSR markers that may be linked to each other and to the disease. Here are two families in which some individuals are affected:

 

Calculate LOD scores for linkage at θ= 0.02 between the disease and SSR43 in Family 2.

TLS Online TPP Program

#Question id: 19118

#Unit 8. Inheritance Biology

You are conducting genetic linkage studies of an autosomal recessive disease whose chromosomal location has not been firmly established. You are focused on two SSR markers that may be linked to each other and to the disease. Here are two families in which some individuals are affected:

                               

Calculate LOD scores for linkage at θ= 0.02 between SSR42 and SSR43 in Family 1.

TLS Online TPP Program

#Question id: 19119

#Unit 8. Inheritance Biology

You are conducting genetic linkage studies of an autosomal recessive disease whose chromosomal location has not been firmly established. You are focused on two SSR markers that may be linked to each other and to the disease. Here are two families in which some individuals are affected:

                     

Calculate LOD scores for linkage at θ= 0.02 between SSR42 and SSR43 in Family 2.