TLS Online TPP Program

#Question id: 15529


When does the T-cell anergy occur?

#Unit 4. Cell Communication and Cell Signaling
  1. During TCR and MHC interaction
  2. CD28 do not interact with B7 family of protein
  3. During autocrine signalling
  4. During paracrine signalling
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TLS Online TPP Program

#Question id: 10460

#Unit 6. System Physiology – Plant

CCT overexpression mutant shows____

TLS Online TPP Program

#Question id: 10461

#Unit 6. System Physiology – Plant

Model of cry1 interactions with COP1/SPA1 in the regulation of photomorphogenesis, what will happen in the dark as well as in the light in wild type condition of cryptochrome?

a) In the dark, COP1/SPA1 acts to degrade transcription factors such as HY5, which is required for photomorphogenesis

b) In the dark, cry1 is activated by phosphorylation and forms a complex with COP1 and SPA1 via the C-terminal domain, preventing them from degrading protein HY5

c) In the light, COP1/SPA1 acts to degrade transcription factors such as HY5, which is required for photomorphogenesis

d) In the light, cry1 is activated directly by blue light and indirectly by blue light induced phosphorylation and forms a complex with COP1 and SPA1 via the C-terminal domain, preventing them from degrading protein HY5

e) In light as well as in dark both case cryptochrome perfom same function such as forming a complex with COP1/ SPA1 thereby promoting an increase in HY5 protein levels and transcription

Which of the following combinations from the above statements of cryptochrome is incorrect?

TLS Online TPP Program

#Question id: 10462

#Unit 6. System Physiology – Plant

During an experiments mutating the conserved cysteine in the LOV1 domain of phot1 does not affect phototropic responsiveness (the seedlings bend toward blue light) whereas the equivalent mutation in LOV2 abolishes the response. What will be the conclusion has been drawn from this experiments?

a)  LOV1 domain is secondarily responsible (primarily responsible is LOV2 domain) for kinase activation and LOV1 is not is coupled with the protein region Jα-helix that’s why it does not affect phototropic responsiveness

b) These studies have demonstrated that LOV2 domain is primarily responsible for kinase activation in response to blue light

c) This is due in part to the position of LOV2 within the phototropin molecule, where it is coupled to a protein region known as the Jα-helix

d) The function of LOV2 domain is thought to play a role in receptor dimerization by accomplishing the kinase activation in response to blue light

Which of the correct conclusion drawn from the above experiment?

TLS Online TPP Program

#Question id: 10463

#Unit 6. System Physiology – Plant

LOV1 and LOV2, each binding a chromophore flavin mononucleotide (FMN), which one of the following statements shows incorrect prediction about LOV domains?

TLS Online TPP Program

#Question id: 10464

#Unit 6. System Physiology – Plant

As with cryptochrome and phytochrome, the N-terminal photosensory region of the phototropins controls the activity of the C-terminal half of the protein, which contains a serine/threonine kinase domain. Following are some statements about photosensory region of the phototropins.

a) The activation of the C-terminal kinase domain then leads to receptor autophosphorylation on multiple serine residues that is required for all phototropin-mediated responses

b) In the dark, the N-terminal region, including the LOV domains, “cages” and inhibits the activity of the kinase domain

c) In the light, the N-terminal region, including the LOV domains, “cages” and inhibits the activity of the kinase domain

d) Absorption of blue photons by the LOV domains results in primary photochemical changes that lead to the uncaging of the kinase domain and its activation by the unfolding of the Jα-helix

Which one of the following combination of above statements is correct?

TLS Online TPP Program

#Question id: 10465

#Unit 6. System Physiology – Plant

This feature is an adaptive, as the redistribution of chloroplasts within the cells modulates light absorption and prevents photodamage, diagram shows of chloroplast distribution patterns in Arabidopsis palisade cells in response to different light intensities;

                                        

m) A-low light, B-high light, C-darkness

n) A-high light, B-darkness, C-low light

Based on the above light intensities, each shows different chloroplasts position such as,

i) chloroplasts avoid sunlight by migrating to the side walls of palisade cells

ii) chloroplasts move to the bottom of the cell, although the physiological function of this position is unclear

iii) chloroplasts optimize light absorption by accumulating at the upper and lower sides of palisade cells

Which of the following correct combinations shows light intensities and chloroplast movements?