#Question id: 23043
#Unit 12. Applied Biology
#Question id: 18650
#Unit 13. Methods in Biology
#Question id: 909
#Unit 1. Molecules and their Interaction Relevant to Biology
Most proteins denature at both high and low pH. At high pH, the ionization of internal tyrosines is thought to be the main destabilizing influence, whereas at low pH, the protonation of buried histidines. A titration curve for the unfolding of the enzyme ribonuclease is shown in Figure. Given the relation between the titration curves for protein unfolding and histidine protonation, which of the following conclusion can be drawn correctly?
A. The sharp transition in graph indicates a highly cooperative process; when the protein starts to unfold, it completes the process rapidly
B. The sharp transition in graph indicates a highly noncooperative process
C. Several buried histidines can ionize when the chain starts to unfold, so that when one goes, they all go together due to cooperative behaviour of protein folding
D. Buried histidine (pK of 4 in this example) becomes accessible to solvent, its pK will shift toward its normal value of 6, significantly steepening its titration curve.
#Question id: 4884
#Unit 8. Inheritance Biology
True breeding brown dogs with genotype aabb were cross to true breeding white dogs with genotype AABB. All F1 offspring having white phenotype were allowed to intercross to produce F2 progeny as following number –
A- - - 118 white,
aa B- 32 black
aa bb 10 brown
A Male Dog with AaBb genotype was cross with female dog with aabb genotype. What is probability of Black phenotype among their offspring if A gene link B gene at 10 map unit at cis configuration?
#Question id: 24252
#Unit 2. Cellular Organization