TLS Online TPP Program

#Question id: 15780


In drosophila, the somatic cells of the hub are able to regulate stem cell proliferation by secreting the paracrine factor Unpaired onto the cells attached to them. Unpaired activates the JAK-STAT pathway in the adjacent germ stem cells to specify their self-renewal. Those cells that are distant from the paracrine factor cannot receive this signal, they begin their differentiation into the sperm cell lineage. This means hub cells act as

#Unit 5. Developmental Biology
  1. Stem cell niches allow controlled self-renewal and also survival of the cells that leave the niche.
  2. Stem cell niches not allow controlled self-renewal but allow survival of the cells that leave the niche.
  3. Stem cell niches allow uncontrolled self-renewal and also division of the cells that leave the niche.
  4. Stem cell niches allow controlled self-renewal and regulate the ratio of cell division to differentiation.