TLS Online TPP Program

#Question id: 15832


Your friends Ben and Jane are contemplating having children and seek your genetic counsel. Ben and Jane are unrelated, but both have younger brothers with the same, extremely rare genetic trait. (In fact, Ben and Jane met at a support group meeting for children and families of children with this rare disorder.) Ben’s parents and Jane’s parents are all unaffected.        
 Assume that the trait is autosomal dominant with 80% penetrance in heterozygotes and 100% penetrance in homozygotes. What is the probability that Ben and Jane’s first child will be affected? 

#Unit 8. Inheritance Biology
  1. 31/240
  2. 11/360
  3. 31/240
  4. 6/50