#Question id: 1501
#Unit 4. Cell Communication and Cell Signaling
When a culture of rodent cells is infected with a DNA tumor virus whose gene products bind to p53 and RB, all the cells take on characteristics of malignancy. If the viral gene coding the p53-binding protein is mutated, but that coding for the RB-binding protein is not mutated, how will infected cells respond?
#Question id: 1502
#Unit 4. Cell Communication and Cell Signaling
The textbook states that cells of patients with adenomatous polyposis coli (APC) “contain a deletion of a small portion of chromosome #5, which was subsequently identified as the site of a tumor-suppressor gene called APC.” In which cells of these patients would you expect to find this chromosomal deletion?
#Question id: 1503
#Unit 4. Cell Communication and Cell Signaling
When the genes responsible for familial breast cancer were sequenced, it was found that the polypeptides they encoded contained a zinc finger motif. What does this suggest to you about the normal functions of the products of these genes?
#Question id: 1504
#Unit 4. Cell Communication and Cell Signaling
Tumor-suppressor genes usually act as .......... genes, and oncogenes usually act as ........... genes.
#Question id: 1505
#Unit 4. Cell Communication and Cell Signaling
Which of the following types of genes have not been identified as oncogenes?
#Question id: 1506
#Unit 4. Cell Communication and Cell Signaling
An oncogene codes for a growth factor receptor that is constitutively active. Of the following statements about a culture of cells expressing this gene, which would you expect to be true?