You are running a human assisted reproduction clinic and providing state-of-the-art genetic diagnostic services. A married couple who already had a child with cystic fibrosis approach you because they wish to have another child, but only if they can be assured that the child will not have cystic fibrosis. You genotype the woman and discover that she is a heterozygote for Del508, the most common mutation causing cystic fibrosis. You suggest that the couple consider first polar body testing, in which several unfertilized oocytes (each with its first polar body) are retrieved from the woman, the first polar bodies are removed, and PCR tests are conducted on DNA from each of the first polar bodies. The couple agrees, and you obtain the following results:

 

the observation that the polar bodies for oocytes #1 and #5 test positive for both Del508 and the wild type sequence, because

#Question id: 5345

#Unit 8. Inheritance Biology

Which of the following above is most probable mode of inheritance?

#Question id: 5346

#Unit 8. Inheritance Biology

The following typical pedigree illustrates the key point that affected children are born to unaffected parents: Which of the following is correct statement?

#Question id: 5347

#Unit 8. Inheritance Biology

The inheritance of a given disorder is recorded in small families shown below: Based on the above limited information, which one of the following inheritance pattern best explains the observations?

#Question id: 5348

#Unit 8. Inheritance Biology

Miniature wings (Xm) in Drosophila result from an X-linked allele that is recessive to the allele for long wings (XL). Following different cross with resulting progeny were possible

Which of the following above offspring is not possible to carry miniature wings?

#Question id: 5349

#Unit 8. Inheritance Biology

The following is the inheritance pattern of a trait under observation:

(i) The trait often follow cris cross inheritance 

(iii) Unaffected father born to affected daughter

The trait is likely to be

#Question id: 5350

#Unit 8. Inheritance Biology

Which of the following most probable mode of genetic disorder?