When a culture of rodent cells is infected with a DNA tumor virus whose gene products bind to p53 and RB, all the cells take on characteristics of malignancy. If the viral gene coding the p53-binding protein is mutated, but that coding for the RB-binding protein is not mutated, how will infected cells respond?

TLS Online TPP Program

#Question id: 34160

#Unit 7. System Physiology – Animal

The causes of ACTH-independent Cushing syndrome include following, EXCEPT? 

TLS Online TPP Program

#Question id: 34161

#Unit 7. System Physiology – Animal

Congenital defects in the enzymes lead to deficient cortisol secretion and the syndrome of congenital adrenal hyperplasia. A cause of severe congenital adrenal hyperplasia in newborns is a loss of function mutation of the gene for the: 

TLS Online TPP Program

#Question id: 34162

#Unit 7. System Physiology – Animal

Gonadal and adrenocortical steroids are of following types, EXCEPT? 

TLS Online TPP Program

#Question id: 34163

#Unit 7. System Physiology – Animal

Which of the following represents the correct sequential pathway for aldosterone synthesis from cholesterol, based on the enzyme-catalyzed steps?

TLS Online TPP Program

#Question id: 34164

#Unit 7. System Physiology – Animal

A newborn is diagnosed with 21β-hydroxylase deficiency. Which of the following downstream consequences is most likely due to impaired glucocorticoid production during fetal life?

TLS Online TPP Program

#Question id: 34165

#Unit 7. System Physiology – Animal

Following statements are regarding thyroid hormone biosynthesis?

I. The basolateral membranes of thyrocytes facing the capillaries contain a antiporter that transports two Na⁺ ions and one I^– ion into the cell with each cycle, against the electrochemical gradient for I^–.

II. Na⁺/I^– symporter (NIS) is capable of producing intracellular I^– concentrations that are 20–40 times as great as the concentration in plasma.

III. TSH induces both NIS expression and the retention of NIS in the basolateral membrane, where it can mediate sustained iodide uptake.