There is evidence that the accumulation of abnormal or damaged proteins due to impairment of the pathway contributes to a number of neurodegenerative diseases, including Alzheimer’s. In contrast, deliberately blocking the pathway in cancer cells could lead to a disruption of protein regulation that in turn could cause the apoptosis of the malignant cells. Accordingly, proteasome inhibitors have been developed for evaluation as anti-tumour agents against selected cancers. Bortezomib is one such inhibitor that targets the 26S proteasome, and in combination with other chemotherapeutic agents has been shown to have therapeutic potential. In contrast to the long-term control, there are several mechanisms by which the activity of an enzyme can be altered almost instantaneously:

A. Reversible inhibition by small molecules (drugs)

B. Product inhibition

C. Allosteric regulation

D. Reversible covalent modification

Which of the above mechanism follow the process of negative-feedback control and ADP-ribosylation respectively?

#Question id: 4817

#Unit 8. Inheritance Biology

How many different gametes can be formed by an organism with genotype AaBbCCddEe, If a, b and c gene are completely link?

#Question id: 4818

#Unit 3. Fundamental Processes

Researchers found a strain of E. coli bacteria that had mutation rates one hundred times higher than normal. Which of the following statements correctly describes the most likely cause of these results?

#Question id: 4819

#Unit 8. Inheritance Biology

Plant with genotype AB/ab is test cross, two genes are linked are 10 map units apart. What proportion of progeny will have the genotype aabb?

#Question id: 4820

#Unit 8. Inheritance Biology

Which of the following gametes are produced in grater proportional by an individual of genotype Ab/aB if the genes are in the same chromosome with some recombination between them?

#Question id: 4821

#Unit 8. Inheritance Biology

What are frequency of recombination  if one cell carry out cross over every 50 cell undergoes meiosis ?

#Question id: 4822

#Unit 8. Inheritance Biology

In a particular species of mammal black hair (B) is dominant to green hair (b) and red eyes (R) are dominant to white eyes (r). If a BbRr individual is mated with a bbrrindividual the expected phenotypic ratio of the offspring is 1 black-red : 1 black-white: 1 green-red : 1 green-white. However, when you mate these individuals you find that the phenotypic ratio of the offspring is 6 black-red :1 black-white : 1 green-red : 6 green-white. What could account for this difference?