TLS Online TPP Program

#Question id: 1513


The kinase activity of ATM is activated in response to DNA damage due to various stresses (e.g., UV irradiation, heat). Activated ATM then triggers following pathways leading to arrest in G1.

A. Chk2 is phosphorylated and, in turn, phosphorylates Cdc25A, thereby marking it for degradation and blocking its role in CDK2 activation.

B. Phosphorylation of p53 stabilizes it, permitting p53-activated expression of genes encoding proteins that cause arrest in G1, promote apoptosis, or participate in DNA repair.

C. Controlling the pool of p53, ATM phosphorylates MDM2 to inactivate it, causing increased stabilization of p53. Another protein p14ARF inhibits the activity of Mdm2 thus stabilizing p53.

Based on the above information, which one of the following statements is correct?

#Unit 4. Cell Communication and Cell Signaling
  1. Gain-of-function of p14ARF and Loss-of-function of p53 leads to tumor formation.

  2. Gain-of-function of p53 and Loss-of-function of Chk2 leads to tumor formation.

  3. Gain-of-function of Cdc25A and Loss-of-function of Chk2 leads to tumor formation.

  4. Gain-of-function of Chk2 and Loss-of-function of MDM2 leads to tumor formation.

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TLS Online TPP Program

#Question id: 29079

#Unit 10. Ecological Principles

You observed the two species of barnacles, P. aurelia and P. caudatum, occupy upper and lower strata of intertidal rocks, respectively. Only when P. caudatum was removed by you from the lowers strata, P. aurelia could occupy both the upper and lower strata. From the choice given below what would be your inference from these observations.

TLS Online TPP Program

#Question id: 29080

#Unit 10. Ecological Principles

Invasive species are less impacted by enemies than native species. An explanation for the better growth and propagation of invasive species in comparison to their native counterparts is provided by which one of the following hypotheses?

TLS Online TPP Program

#Question id: 29081

#Unit 10. Ecological Principles

If a predator has multiple prey, abundance of prey are not strongly positively correlated then as one prey species, which of the following graph correctly represent this prediction;

TLS Online TPP Program

#Question id: 29082

#Unit 10. Ecological Principles

There are some major anthropogenic atmospheric gases causing the greenhouse effect, which of the following gas has the most powerful greenhouse effect?

TLS Online TPP Program

#Question id: 29083

#Unit 10. Ecological Principles

Relative absorption per ppm of increase is;
I- CO2
II- Methane 
III- Nitrous oxide
IV- Chlorofluorocarbon
Arrange in decreasing order

TLS Online TPP Program

#Question id: 29084

#Unit 10. Ecological Principles

Which of the following gases has the major contribution to global warming?