TLS Online TPP Program

#Question id: 1514


Following statements are regarding to multiple signaling pathways in vertebrate cells that regulate outer mitochondrial membrane permeability and apoptosis.

A. In healthy cells, the anti-apoptotic protein Bcl-2, or its homolog Bcl-xL, binds to Bak or Bax pro-apoptotic proteins, blocking the ability of Bak or Bax to oligomerize and form pores in the outer mitochondrial membrane.

B. The presence of specific trophic factors (e.g., NGF) leads to activation of their cognate receptor tyrosine kinases (e.g., TrkA) and inactivation of the PI-3 kinase–PKB (protein kinase B) pathway.

C. PKB phosphorylates Bad, and phosphorylated Bad forms a complex with a cytosolic 14-3-3 protein. This sequestered Bad is unable to bind to Bcl-2.

D. In the absence of trophic factors, nonphosphorylated Bad binds to Bcl-2, releasing Bax and Bak and allowing them to form oligomeric membrane pores and holes.

E. DNA damage or ultraviolet irradiation leads to induction of synthesis of the BH3-only Puma protein. Puma binds to Bak and Bax as well as to Bcl-2, allowing Bak and Bax to form oligomeric pores.

F. Removal of a cell from its substratum disrupts integrin signaling, leading to release of the BH3-only Bim protein from the cytoskeleton. Bim also binds to Bak and Bax to promote pore formation.

Which of the following is incorrect?

#Unit 4. Cell Communication and Cell Signaling
  1. A and C

  2. A, B, C and D

  3. C, E and F

  4. B only

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TLS Online TPP Program

#Question id: 10210

#Unit 6. System Physiology – Plant

Some xanthophylls also participate in energy dissipation such as in light conversion of Violaxanthin to Zeaxanthin with antheraxanthin as the intermediate and vice-versa, which of the following statements is CORRECT?

a.) The conversion of Violaxanthin to Zeaxanthin a singlet oxygen is removed with the help of co-factor Ascorbate and violaxanthin de-epoxidase under high PPFD

b.) Zeaxanthin is oxidised into violaxanthin with the help of NADPH and oxygen under low PPFD

c.) Conversion of Violaxanthin to Zeaxanthin a singlet oxygen is removed with the help of NADPH and water under low PPFD

d.) Zeaxanthin is oxidised into violaxanthin in presence of enzyme known as violaxanthin de-epoxidase and co-factor Ascorbate under high PPFD

TLS Online TPP Program

#Question id: 15236

#Unit 13. Methods in Biology

Polyacrylamide gels are formed from the polymerisation of acrylamide monomer in the presence of
A) Agarose
B) TEMED
C) APS
D) bis-acrylamide

TLS Online TPP Program

#Question id: 18622

#Unit 13. Methods in Biology

Variants of PCR has been devised for mutational analysis
a) AS PCR
b) Site directed mutagenesis
c) Overlap extension PCR
d) Mega primer PCR

TLS Online TPP Program

#Question id: 19312

#Unit 4. Cell Communication and Cell Signaling

Hm1‐resistant maize plants are resistance for 

TLS Online TPP Program

#Question id: 2095

#Unit 2. Cellular Organization

Glycolipids and glycoproteins are especially abundant in the