Tumor-suppressor genes generally encode proteins that in one way or another inhibit cell proliferation. Loss-of-function mutations in one or more of these proliferation inhibitory proteins contribute to the development of many cancers. Prominent among the classes of proteins encoded by tumor-suppressor genes are:

A. Intracellular proteins that regulate or inhibit entry into the cell cycle

B. Receptors or signal transducers for secreted hormones or developmental signals that inhibit cell proliferation

C. Checkpoint pathway proteins that arrest the cell cycle if DNA is damaged

D. Proteins that promote apoptosis

Following genes belongs to the above class-

i. p53

ii. Rb

iii.TGF- β

iv. Caspase 3 and 7

which of the following match is correct?

TLS Online TPP Program

#Question id: 31147

#Unit 2. Cellular Organization

When a mutant protein disulfide isomerase lacking KDEL residues is synthesized in cultured fibroblasts, resulting:

TLS Online TPP Program

#Question id: 31148

#Unit 2. Cellular Organization

KDEL receptor, located in the different locations except?

TLS Online TPP Program

#Question id: 31149

#Unit 2. Cellular Organization

KDEL receptor and other membrane proteins that are transported Golgi to ER contain:

TLS Online TPP Program

#Question id: 31150

#Unit 2. Cellular Organization

The most common CFTR mutation is a deletion of a phenylalanine at position 508 in the protein sequence. This mutation prevents:

TLS Online TPP Program

#Question id: 31151

#Unit 2. Cellular Organization

Mutation in a structural gene that codes for the lysosomal hydrolase that causes disease, called:

TLS Online TPP Program

#Question id: 31152

#Unit 2. Cellular Organization

Incubation of cell extracts with a nonhydrolyzable derivative of GTP for dynamin in the pinching off of vesicles during endocytosis, resulting: