Following statements are regarding to apoptosis.

A. In the worm apoptotic pathway, CED-3 (caspase-9 in mammals) is a protease required to destroy cell components during apoptosis.

B. CED-4 (Apaf-1) was able to accelerate the autoproteolytic cleavage and activation of purified CED-9

C. Once EGL-1 causes dissociation of the CED-4/CED-9 complex, the released CED-4 dimer joins with three other CED-4 dimers to make an octamer, which then activates CED-3

D. Many apoptotic stimuli lead to damage of the outer mitochondrial membrane, causing release into the cytosol of several proteins that stimulate apoptosis. In particular, cytochrome c released from mitochondria activates Apaf-1, which in turn activates caspase-3 and 7.

Which of the following combination is incorrect?

TLS Online TPP Program

#Question id: 33359

#Unit 1. Molecules and their Interaction Relevant to Biology

The protein calcineurin binds to the protein calmodulin with an association rate of 8.9 X10³ M^-1s^-1 and an overall dissociation constant, Kd, of 10 nM. The dissociation rate, kd

TLS Online TPP Program

#Question id: 33360

#Unit 1. Molecules and their Interaction Relevant to Biology

a. HbS (sickle-cell Hb): substitutes a Val for a Glu on the surface

b. Hb Cowtown: eliminates an ion pair involved in T-state stabilization

c. Hb Memphis: substitutes one uncharged polar residue for another of similar size on the surface

d. Hb Bibba: substitutes a Pro for a Leu involved in an α helix

Which Hb variant least likely to cause pathological symptoms

TLS Online TPP Program

#Question id: 33361

#Unit 1. Molecules and their Interaction Relevant to Biology

a. Hb Cowtown: eliminates an ion pair involved in T-state stabilization

b. Hb Milwaukee: substitutes a Glu for a Val

c. Hb Providence: substitutes an Asn for a Lys that normally projects into the central cavity of the tetramer

d. Hb Philly: substitutes a Phe for a Tyr,

Which Hb variant will not bind to BPG

TLS Online TPP Program

#Question id: 33362

#Unit 1. Molecules and their Interaction Relevant to Biology

a. Hb Cowtown: eliminates an ion pair involved in T-state stabilization

b. Hb Milwaukee: substitutes a Glu for a Val

c. Hb Providence: substitutes an Asn for a Lys that normally projects into the central cavity of the tetramer

d. Hb Philly: substitutes a Phe for a Tyr

Which Hb variant will have changed pI as compared to HbA

TLS Online TPP Program

#Question id: 33363

#Unit 1. Molecules and their Interaction Relevant to Biology

An antibody binds to an antigen with a Kd of 5 X10^-8 M. At what concentration of antigen will θ be 0.2

TLS Online TPP Program

#Question id: 33364

#Unit 1. Molecules and their Interaction Relevant to Biology

An antibody binds to an antigen with a Kd of 5 X10^-8 M. At what concentration of antigen will θ be 0.5