Which of the following statements are true regarding to gain-of-function and loss-of-function mutations with respect to cancer.

A gain-of-function mutation converts a proto-oncogene into an oncogene. Such mutations are dominant and require alteration of single allele. A loss-of-function mutation occurs in tumor-suppressor genes, abrogating their function in preventing cancer. Such mutations are recessive and require alteration of both alleles.

A gain-of-function mutation converts a proto-oncogene into an oncogene. Such mutations are dominant and require alteration of both alleles. A loss-of-function mutation occurs in tumor-suppressor genes, abrogating their function in preventing cancer. Such mutations are recessive and require alteration of single allele.

A gain-of-function mutation occurs in tumor-suppressor genes. Such mutations are dominant and require alteration of single allele. A loss-of-function mutation converts a proto-oncogene into an oncogene, abrogating their function in preventing cancer. Such mutations are recessive and require alteration of both alleles.

A gain-of-function mutation occurs in tumor-suppressor genes. Such mutations are dominant and require alteration of both alleles. A loss-of-function mutation converts a proto-oncogene into an oncogene, abrogating their function in preventing cancer. Such mutations are recessive and require alteration of single allele.