Practice Questions

TLS Online TPP Program

#Question id: 1537

Transformation of mature cells may also occur due to aberrant expression of stemness genes, resulting in cell clones with a dedifferentiated phenotype and self-renewing capacity resembling stem cells. Recent experimental evidence supporting this proposal has been provided with the induction of adult somatic cells into pluripotent stem (iPS) cells through ectopic expression of four genes encoding the pluripotency factors Oct4 and Sox2, the transcription factor Klf4, and the oncoprotein c-Myc in mouse or human fibroblasts. However, along with pluripotency comes the capability of generating teratomas. On the basis of the above information which of the following outcome is most appropriate?

#Unit 4. Cell Communication and Cell Signaling

This tumorigenicity could be partly explained by the enforced expression of Oct4.
This tumorigenicity could be partly explained by the enforced expression of Sox2.
This tumorigenicity could be partly explained by the enforced expression of Klf4.
This tumorigenicity could be partly explained by the enforced expression of c-Myc.