During your study of the gene for an enzyme you have isolated an amber mutation in the middle of the gene which produces a truncated form of the enzyme. By placing a +1 frameshift mutation a short distance before the amber mutation and a –1 frameshift mutation a short distance after the amber mutation you create a triple mutant that restores expression of a functional, full-length enzyme. 

a) +1 frameshift puts the amber mutation out of frame so that it is no longer read as a stop.

b) -1 frameshift is inserted after the amber so that no longer read as a stop.

c)  -1 frameshift is inserted after the amber to restore the frame of the end of the protein.

d) +1 frameshift puts the amber mutation out of frame so that it restore the frame of the end of the protein.

Which of the following is the correct prediction about the frame shift mutation?

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#Question id: 21650

#Unit 11. Bioinformatics

BLOSUM matrix is used for

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#Question id: 21668

#Unit 11. Bioinformatics

Phylogenetic tree provides information about

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#Question id: 21685

#Unit 11. Bioinformatics

The sequence CGAATTTGG is matched globally with four sequences in a database. The sequence that will give the highest similarity score taking match=1, mismatch=0 and gap penalty=minus1 is

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#Question id: 21746

#Unit 11. Bioinformatics

Computational Prediction of protein folding assumes that

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#Question id: 24381

#Unit 11. Bioinformatics

Which one of the following programs is used for finding distantly related (or remote) protein homologs?

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#Question id: 24382

#Unit 11. Bioinformatics

Which one of the following is used for global alignment of two protein sequences?