Consider a heritable autosomal disease with an incidence in the population of 1 per thousand. On average, individuals with the disease have 80% as many children as the population average. In answering the various parts of this question, assume that mating is random. Now assume that the mutation rate is zero, that the disease is recessive, and that the disease allele is maintained in the population by heterozygote advantage. Calculate the heterozygote advantage,

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#Question id: 27092

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following ions are essentially involved in EF hand motifs

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#Question id: 27093

#Unit 1. Molecules and their Interaction Relevant to Biology

Say a, b, c, d, e, f, g  are the amino acid forming αα motif / Coiled-coils then which of the condition must be followed to form perfect αα motif / Coiled-coil

(1) 'a' & 'd' are hydrophobic residues

(2) 'a' & 'd' are hydrophilic residues

(3) 'e' and 'g' are found to be charged amino acids

(4) 'e' and 'g' are found to be uncharged amino acids

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#Question id: 27094

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following is incorrect regarding the βαβ Motif

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#Question id: 27095

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following is correct regarding the Type I β turn positions  Ramachandran plot

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#Question id: 27096

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following is incorrect regarding the Type II β turns

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#Question id: 27097

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following is correct regarding the β turns

(1) In Type I β turn i+1 lies in RHH region while i+2 lies near BS region

(2) In Type II β turn i+1 lies in BS while i+2 lies in below LHH

(3) In Type I’ β i+1and i+2 in near LHH which virtually not allowed region for most of amino acid except Gly

(4) In Type II’ β i+2 lies at 00 psi and i+1 in lower right region both i+2 and   i+1  must be Gly