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TLS Online TPP Program

#Question id: 1849

Tetanus toxoid is usually given to humans:

#Unit 4. Cell Communication and Cell Signaling

  1. Absorbed to aluminum hydroxide

  2. With complete Freund's adjuvant

  3. Without the addition of any other agent

  4. Together with the toxin

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TLS Online TPP Program

#Question id: 2835

#Unit 2. Cellular Organization

An enhancer

a. can be located upstream of a promoter.

b. can be located downstream of a promoter.

c. can be located a variable distance from the promoter.

d. is always located within 1 kb of the promoter.

e. can be cell-type-specific.
TLS Online TPP Program

#Question id: 2836

#Unit 2. Cellular Organization

The fact that a specific protein leaves a “footprint” on a DNA molecule is indicative of
a. a lack of interaction between the specific protein and DNA.
b. protection from DNAse by the specific protein.
c. binding of the specific protein to all types of DNA.
d. binding of the specific protein to a specific sequence of DNA.
TLS Online TPP Program

#Question id: 2837

#Unit 2. Cellular Organization

The C-terminal activation domain of transcriptional activators is capable of
a. binding to DNA.                 
b. stimulating transcription.
c. interaction with other transcriptional machinery.
d. functioning in a fusion with a DNA-binding domain from an unrelated transcriptional activator.
TLS Online TPP Program

#Question id: 2838

#Unit 2. Cellular Organization

You want to study the potential interaction between nucleosome-bound DNA and a specific histone deacetylase. You decide to perform an electrophoretic mobility shift assay (EMSA). You use a 32P end-labelled, linear template DNA that contains two nucleosome positioning sites. You assemble two nucleosomes on the DNA template before incubation with and without the histone deacetylase. For some reactions, you use unmodified nucleosomes. For other reactions, you use nucleosomes that are methylated at lysine 36 of the histone protein H3.

A. The histone deacetylase binds nucleosome bound-DNA in lanes 1, 2, 3, and 4.

B. The histone deacetylase binds nucleosome bound-DNA in lanes 3& 4.

C. The histone deacetylase seems to recognize methylated nucleosomes at lysine 36 of histone H3 in lane 1, 2 & 3 better than unmethylated nucleosomes in lane 4 &5

D. The histone deacetylase seems to recognize methylated nucleosomes at lysine 36 of histone H3 in lane 1 & 2 better than unmethylated nucleosomes in lane 3 &4
TLS Online TPP Program

#Question id: 2839

#Unit 2. Cellular Organization

Consider for correct match

I. All the different members of family of genes and proteins are sufficiently similar in sequence to suggest a common ancestral sequence.

A. Homologous

II. Sequences that presumably diverged as a result of gene duplication

B. Paralogous

III. Sequences that arose because of speciation

C. Orthologous

TLS Online TPP Program

#Question id: 2840

#Unit 2. Cellular Organization

An experimental setup provided the assay for identifying factors that facilitate transcription in the presence of chromatin. A factor called FACT (facilitates chromatin transcription) functions as