The product(s) of lactate dehydrogenase under anaerobic conditions is (are)

A) pyruvic acid.

B) NAD+.

C) NADH.

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#Question id: 12481

#Unit 2. Cellular Organization

Following statements are regarding to Kinetochore-microtubule interaction in S. cerevisiae.

A. In the simple kinetochore of S. cerevisiae, a protein complex called CBF3 associates with specialized, centromere-specific form of histone H3, called CENP-A.

B. The Ndc80 complexes initially make lateral interactions with a spindle microtubule and subsequently interact with a Dam1 complex, which forms a ring around the end of the microtubule. This interaction results in an end-on attachment of the centromere to the

spindle microtubule.

C. Microtubules that “capture” kinetochores are selectively stabilized by a reduction in the rate of catastrophes, which increases the chance that the attachment will persist.

D. With the two kinetochores attached to opposite poles, the duplicated chromosome is now under tension, being pulled in both directions by the one sets of kinetochore microtubules.

Which of the following combinations is correct?

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#Question id: 12482

#Unit 2. Cellular Organization

The Rb protein has been called the “master brake” of the cell cycle. How the Rb protein acts as a cell cycle brake?

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#Question id: 12483

#Unit 2. Cellular Organization

ATM and ATR are protein kinases that become activated following specific types of DNA damage. 

A. ATM becomes activated in response to double‐strand breaks, which are detected by the MRN protein complex. 

B. ATR becomes activated by protein‐coated ssDNA that forms when replication forks become stalled or the DNA is being repaired after various types of damage.

C. ATR phosphorylates and activates the checkpoint kinase Chk2, which phosphorylates p53. D. ATM phosphorylates and activates the checkpoint kinase Chk1, which phosphorylates and inactivates the phosphatase Cdc25.

Which of the following combination is incorrect?

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#Question id: 12484

#Unit 2. Cellular Organization

Match the following.

Column I	Column II
A. APC/CCdc20	i . responsible for ubiquitinating proteins, such as mitotic cyclins
B. APC/CCdh1	ii. responsible for destroying proteins, such as securin
	iii. promotes the metaphase–anaphase transition
	iv. Promotes exit from mitosis

Which of the following is correct?

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#Question id: 12485

#Unit 2. Cellular Organization

Following statements are regarding to the centrosome cycle of an animal cell.

A. During G1, the daughter procentrioles continue to elongate.

B. During S phase, daughter procentrioles form adjacent to maternal centrioles so that two pairs of centrioles become visible within the centrosome. 

C. During G2 phase, the centrosome contains a single pair of centrioles.

D. At the beginning of mitosis, the centrosome splits, with each pair of centrioles becoming part of its own centrosome. As they separate, the centrosomes organize the microtubule fibres that make up the mitotic spindle.

Which of the following option is correct? 

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#Question id: 12486

#Unit 2. Cellular Organization

Which of the following process occur in prometaphase?