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TLS Online TPP Program
#Question id: 17994
#Unit 8. Inheritance Biology
Consider a heritable autosomal disease with an incidence in the population of 1 per thousand. On average, individuals with the disease have 80% as many children as the population average. In answering the various parts of this question, assume that mating is random. What mutation rate would be required to maintain the observed incidence of the disease in the population if the disease is dominant?
TLS Online TPP Program
#Question id: 17995
#Unit 8. Inheritance Biology
Consider a heritable autosomal disease with an incidence in the population of 1 per thousand. On average, individuals with the disease have 80% as many children as the population average. In answering the various parts of this question, assume that mating is random. What mutation rate would be required to maintain the observed incidence of the disease in the population if the disease is recessive?
TLS Online TPP Program
#Question id: 17996
#Unit 8. Inheritance Biology
Consider a heritable autosomal disease with an incidence in the population of 1 per thousand. On average, individuals with the disease have 80% as many children as the population average. In answering the various parts of this question, assume that mating is random. Now assume that the mutation rate is zero, that the disease is recessive, and that the disease allele is maintained in the population by heterozygote advantage. Calculate the heterozygote advantage,
TLS Online TPP Program
#Question id: 18081
#Unit 8. Inheritance Biology
The interaction of selection and inbreeding in determining the incidence of autosomal recessive diseases. Consider a gene in which recessive mutations occur at a rate of 10-5. Assume a selective disadvantage S of 0.4 in homozygotes for the recessive allele. What is the frequency of the recessive allele (q). And calculate the incidence of the disease. Assume random mating.
TLS Online TPP Program
#Question id: 18082
#Unit 8. Inheritance Biology
The interaction of selection and inbreeding in determining the incidence of autosomal recessive diseases. Consider a gene in which recessive mutations occur at a rate of 10-5. Assume a selective disadvantage S of 0.4 in homozygotes for the recessive allele. Now assume that, for thousands of generations, 10% of all children have been products of first-cousin matings (the remaining 90% being products of random matings). Calculate the steady-state value of q. Also calculate the incidence of the disease at steady state.
TLS Online TPP Program
#Question id: 18083
#Unit 8. Inheritance Biology
The interaction of selection and inbreeding in determining the incidence of autosomal recessive diseases. Consider a gene in which recessive mutations occur at a rate of 10-5. Assume a selective disadvantage S of 0.4 in homozygotes for the recessive allele. Would q be expected to rise, fall, or remain unchanged during the first 10 generations after the cessation of inbreeding, Briefly justify your answer. What numerical value would q approach after thousands of generations with no inbreeding?