You are conducting genetic linkage studies of an autosomal recessive disease whose chromosomal location has not been firmly established. You are focused on two SSR markers that may be linked to each other and to the disease. Here are two families in which some individuals are affected:

                             

Calculate LOD scores for linkage at θ= 0.02 between the disease and SSR42 in Family 2.

#Question id: 11881

#General Aptitude

#Question id: 8294

#Unit 9. Diversity of Life Forms

The common ancestors of birds and mammals were very early (stem) reptiles, which almost certainly possessed three-chambered hearts (two atria, one ventricle). Birds and mammals, however, are alike in having four-chambered hearts (two atria, two ventricles). The fourchambered hearts of birds and mammals are best described as ________.

#Question id: 891

#Unit 1. Molecules and their Interaction Relevant to Biology

The folding pathways of some proteins require two enzymes that catalyze isomerization reactions such as,

a) Peptide prolyl isomerase (PPI)  catalyzes the elimination of folding intermediates with inappropriate disulfide cross-links

b) Protein disulfide isomerase (PDI) enzyme that catalyzes the interchange, or shuffling, of disulfide bonds until the bonds of the native conformation are formed

c) Peptide prolyl cis-trans isomerase (PPI) catalyzes the interconversion of the cis and trans isomers of Proline residue peptide bonds

d) Peptide prolyl isomerase (PPI) can be a fast step in the folding of proteins that contain some Pro peptide bonds in the cis conformation

Which of the following combinations is correct about protein folding pathways?

#Question id: 19227

#Unit 12. Applied Biology

#Question id: 1087

#Unit 4. Cell Communication and Cell Signaling

Scientists have found that extracellular matrix components may induce specific gene expression in embryonic tissues such as the liver and testes. For this to happen, there must be direct communication between the extracellular matrix and the developing cells. Which kind of transmembrane protein would most likely be involved in this kind of induction?