#Question id: 2893
#Unit 2. Cellular Organization
Which of the following statement regarding the Nucleosome-remodeling complexes is CORRECT?
#Question id: 2894
#Unit 2. Cellular Organization
Which of the following statements is INCORRECT regarding the assembly of DNA into higher-order chromatin structure?
I. Histone H1 is not part of the histone octamer, but binds to linker DNA and is responsible for higher-order chromatin structure.
II. The 30 nm fibers of a chromosome are attached to a/an RNA-protein scaffold that holds the fibers in large loops.
III. It is not possible for linear DNA to be supercoiled. Only circular DNA, which has no ends, can have regions of supercoiling.
IV. Core histones lacking their amino-terminal tails are capable of forming 30-nm fibers as they help to stabilize the 30-nm fiber in internucleosomal interactions.
#Question id: 2895
#Unit 2. Cellular Organization
Match the following histone modifying enzymes with the respective functions they catalyze.
COLUMN I COLUMN II
1. NuRD, SIR2 complex a. Histone Acetyltransferase Complexes
2. LSD1, JHMD3 b. Histone Deacetylase Complexes
3. SUV39, DOT1 c. Histone Demethylases
4. P300/CBP, PCAF d. Histone Methyltransferases
#Question id: 2896
#Unit 2. Cellular Organization
Different modification states of the residue Lys-9 on the tail of histone H3 could be interpreted to have different meanings. One example of how a histone modification can apparently influence a second modification present nearby is illustrated by the Drosophila HP1 protein. Which of the following statement is correct regarding this kind of epigenetic regulation?
#Question id: 2897
#Unit 2. Cellular Organization
The transcription of most protein coding genes in mammals (~70 percent) occurs at a lower rate than at TATA box–containing and initiator-containing promoters and begins at any of several alternative start sites within regions of about 100–1000 bp that have an unusually high frequency of CG sequences. Which one of the following best explains it?
#Question id: 2898
#Unit 2. Cellular Organization
The human genome is composed of many different types of DNA sequences, the majority of which do not encode proteins. From the following distribution and amount of each of the various types of sequences determine which of these is CORRECTLY expressed?