Practice Questions

TLS Online TPP Program

#Question id: 2581

Match the following toxins (Column I) with their effects (Column II) on actin.

Column I

Column II

A. Cytochalasin D

i. Enhances nucleation by binding and stabilizing actin dimers and thereby lowering the critical concentration.

B. Latrunculin

ii. Binds at the interface between subunits in

F-actin, locking adjacent subunits together and preventing actin filaments from depolymerizing.

C. Jasplakinolide

iii. Depolymerizes actin filaments by binding to the (+) end of F-actin, where it blocks further addition of subunits.

D. Phalloidin

iv. Binds and sequesters G-actin, inhibiting it from adding to a filament end.

#Unit 2. Cellular Organization

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Column I	Column II
A. Cytochalasin D	i. Enhances nucleation by binding and stabilizing actin dimers and thereby lowering the critical concentration.
B. Latrunculin	ii. Binds at the interface between subunits in F-actin, locking adjacent subunits together and preventing actin filaments from depolymerizing.
C. Jasplakinolide	iii. Depolymerizes actin filaments by binding to the (+) end of F-actin, where it blocks further addition of subunits.
D. Phalloidin	iv. Binds and sequesters G-actin, inhibiting it from adding to a filament end.