#Question id: 15376
#Unit 13. Methods in Biology
#Question id: 21954
#Unit 2. Cellular Organization
#Question id: 7195
#Unit 5. Developmental Biology
Given below are some of the statements regarding toll signalling pathway in drosophila.
A. Dorsal protein is a transcription factor with homology to the Rel/nuclear factor kappa B (NFκB) family of vertebrate transcription factors, which are involved in regulation of gene expression in vertebrate immune responses.
B. Toll signalling pathway is also used in the adult fly in defense against infection.
C. In the Drosophila embryonic Toll pathway Dorsal is held inactive in the nucleus by the protein Cactus.
D. The ligand for Toll is a fragment of the protein Easter, which is generated in the ventral vitelline space by the protease Spatzle.
E. When Toll is activated by binding the Spätzle fragment, its cytoplasmic domain binds a complex of the adaptor proteins dMyD88 and Tube. Tube interacts with, and activates, the protein kinase Pelle.
F. Activation of Pelle leads to the dephosphorylation of Cactus. This releases Dorsal, which is then free to enter a nucleus.
Choose the most appropriate combination of correct statements:
#Question id: 32710
#Unit 1. Molecules and their Interaction Relevant to Biology
#Question id: 13150
#Unit 8. Inheritance Biology
