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TLS Online TPP Program

#Question id: 2871

With respect to X-chromosome inactivation in females, which, if any, of the following statements is incorrect?

#Unit 2. Cellular Organization

  1. X-inactivation first occurs in the preimplantation female mammalian embryo.

  2. One of the two X chromosomes in each diploid cell of a normal woman is randomly selected to undergo X-inactivation and becomes highly condensed.

  3. The process involves epigenetic silencing of each gene on one of the two X chromosomes, either the maternal X chromosome or the paternal X chromosome.

  4. Once the decision is made to inactivate a paternal X or the maternal X in a cell, all descendant cells will continue with that pattern of X-inactivation.

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TLS Online TPP Program

#Question id: 2836

#Unit 2. Cellular Organization

The fact that a specific protein leaves a “footprint” on a DNA molecule is indicative of
a. a lack of interaction between the specific protein and DNA.
b. protection from DNAse by the specific protein.
c. binding of the specific protein to all types of DNA.
d. binding of the specific protein to a specific sequence of DNA.
TLS Online TPP Program

#Question id: 2837

#Unit 2. Cellular Organization

The C-terminal activation domain of transcriptional activators is capable of
a. binding to DNA.                 
b. stimulating transcription.
c. interaction with other transcriptional machinery.
d. functioning in a fusion with a DNA-binding domain from an unrelated transcriptional activator.
TLS Online TPP Program

#Question id: 2838

#Unit 2. Cellular Organization

You want to study the potential interaction between nucleosome-bound DNA and a specific histone deacetylase. You decide to perform an electrophoretic mobility shift assay (EMSA). You use a 32P end-labelled, linear template DNA that contains two nucleosome positioning sites. You assemble two nucleosomes on the DNA template before incubation with and without the histone deacetylase. For some reactions, you use unmodified nucleosomes. For other reactions, you use nucleosomes that are methylated at lysine 36 of the histone protein H3.

A. The histone deacetylase binds nucleosome bound-DNA in lanes 1, 2, 3, and 4.

B. The histone deacetylase binds nucleosome bound-DNA in lanes 3& 4.

C. The histone deacetylase seems to recognize methylated nucleosomes at lysine 36 of histone H3 in lane 1, 2 & 3 better than unmethylated nucleosomes in lane 4 &5

D. The histone deacetylase seems to recognize methylated nucleosomes at lysine 36 of histone H3 in lane 1 & 2 better than unmethylated nucleosomes in lane 3 &4
TLS Online TPP Program

#Question id: 2839

#Unit 2. Cellular Organization

Consider for correct match

I. All the different members of family of genes and proteins are sufficiently similar in sequence to suggest a common ancestral sequence.

A. Homologous

II. Sequences that presumably diverged as a result of gene duplication

B. Paralogous

III. Sequences that arose because of speciation

C. Orthologous

TLS Online TPP Program

#Question id: 2840

#Unit 2. Cellular Organization

An experimental setup provided the assay for identifying factors that facilitate transcription in the presence of chromatin. A factor called FACT (facilitates chromatin transcription) functions as 
TLS Online TPP Program

#Question id: 2841

#Unit 2. Cellular Organization

To duplicate a chromosome, at least half of the nucleosomes on the daughter chromosomes must be newly synthesized. But histone proteins as new and old occupies strands differently as