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TLS Online TPP Program

#Question id: 2888

Repressive complexes have been discovered that are composed of multiple repressing proteins bound to RNAs many kilobases in length that do not contain long open reading frames and are consequently called long noncoding RNAs or lncRNAs. Which of the following statements is correct regarding the regulation of these lncRNAs?

#Unit 2. Cellular Organization

  1. X inactivation is controlled by a roughly 100-kb domain on the X chromosome called the X-inactivation center that encodes a lncRNA known as XIST that is responsible for inactivation of the maternally derived chromosome.

  2. Depletion of a 2.2-kb noncoding RNA expressed from the HOXC locus by siRNA unexpectedly led to derepression of the HOXD locus, a roughly 40-kb region on another chromosome encoding several Hox proteins and multiple other noncoding RNAs, in these cells.

  3. HOTTIP lncRNA, which is transcribed from the 5’end of the HOXA locus, is proposed to coordinate the activation of HOXA genes by binding to a histone H3 lysine 9 methylase represents the cis activation by lnc-RNAs.

  4. In humans, but not in mice, a lncRNA called XACT has been discovered to associate with multiple sites along the full length of the active X chromosome and is postulated to contribute to repression of gene activity on that chromosome.

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TLS Online TPP Program

#Question id: 15716

#Unit 11. Evolution and Behavior

Evolutionary biology extends and amplifies the explanation of biological phenomena. It complements studies of the proximate causes (immediate, mechanical causes) of biological phenomena If we ask what causes a male bird to sing, the proximate causes include the action of testosterone or other hormones
TLS Online TPP Program

#Question id: 15717

#Unit 11. Evolution and Behavior

 In The Origin of Species, Darwin propounded two major hypotheses:
TLS Online TPP Program

#Question id: 15718

#Unit 11. Evolution and Behavior

Christians interpreted the biblical account of Genesis literally and concluded that each species had been created individually by God in the same form it has today. This belief is known as

TLS Online TPP Program

#Question id: 15719

#Unit 11. Evolution and Behavior

Carolus Linnaeus (1707–1778), who established the framework of modern taxonomy in his Systema Naturae (1735), won worldwide fame for his exhaustive classification of plants and animals, undertaken in the hope of discovering the pattern of the creation. Linnaeus classified,
TLS Online TPP Program

#Question id: 15720

#Unit 11. Evolution and Behavior

The geologists ________ expounded the principle of uniformitarianism, holding that the same processes operated in the past as in the present and that the data of geology should therefore be explained by causes that we can now observe.
TLS Online TPP Program

#Question id: 15721

#Unit 11. Evolution and Behavior

Lamarck argued that species differ from one another because they have different needs, and so use certain of their organs and appendages. This hypothesis is known as?