TLS Online TPP Program

#Question id: 2912


HOTAIR is a lncRNA whose gene is found in the Hox C cluster in humans, but it acts by regulating expression of the Hox D genes on another chromosome (in trans) by recruiting to that locus Polycomb Repressive Complex 2. Which of the following statements is/are correct regarding this regulation?

#Unit 2. Cellular Organization
  1. PRC2 adds trimethyl groups to lysine 27 of histone H3, a mark (H3K27me3) associated with repressed gene expression.

  2. HOTAIR also recruits a second complex that removes histone modifications typically associated with active genes.

  3. Deleting the PRC2-binding domain of HOTAIR destroys its regulatory functions in both development and cancer.

  4. All of the above

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TLS Online TPP Program

#Question id: 4701

#Unit 11. Evolution and Behavior

Charles Darwin discussed all of the following EXCEPT:

TLS Online TPP Program

#Question id: 2973

#Unit 2. Cellular Organization

Following statements are regarding to the spindle position checkpoint pathway in budding yeast.

A. During interphase and early mitosis, Cdc14 is sequestered and inactivated in the nucleolus. Inactive Tem1-GDP associates with the spindle pole body (SPB) nearest to the bud as soon as the mitotic spindle forms.

B. If chromosome segregation occurs properly, extension of the spindle microtubules inserts the daughter SPB into the bud, causing Tem1 to be activated by an unknown mechanism.

C. Tem1-GDP activates a protein kinase cascade, which then promotes the release of active Cdc14 from the nucleolus and exit from mitosis.

D. If the spindle apparatus fails to place the daughter SPB in the bud, Kin4 (cyan), an inhibitor of Tem1, is recruited from the parent cell cortex to the parent-cell-located SPB and maintains Tem1 in the GTP-bound form, and mitotic exit does not occur.

Which of the following are correct?

TLS Online TPP Program

#Question id: 2447

#Unit 2. Cellular Organization

In the axonemes, the arrangement of nine outer doublet microtubules, as well as the protofilament number of each outer doublet, is specified by

TLS Online TPP Program

#Question id: 28333

#Unit 5. Developmental Biology

 Genes that are active in the mother to make products for the early development of the offspring is called___

TLS Online TPP Program

#Question id: 778

#Unit 1. Molecules and their Interaction Relevant to Biology

Inactive miRNA undergoes how many cleavages before incorporation into the RISC complex?