Following statements are regarding to the spindle position checkpoint pathway in budding yeast.

A. During interphase and early mitosis, Cdc14 is sequestered and inactivated in the nucleolus. Inactive Tem1-GDP associates with the spindle pole body (SPB) nearest to the bud as soon as the mitotic spindle forms.

B. If chromosome segregation occurs properly, extension of the spindle microtubules inserts the daughter SPB into the bud, causing Tem1 to be activated by an unknown mechanism.

C. Tem1-GDP activates a protein kinase cascade, which then promotes the release of active Cdc14 from the nucleolus and exit from mitosis.

D. If the spindle apparatus fails to place the daughter SPB in the bud, Kin4 (cyan), an inhibitor of Tem1, is recruited from the parent cell cortex to the parent-cell-located SPB and maintains Tem1 in the GTP-bound form, and mitotic exit does not occur.

Which of the following are correct?

#Question id: 11546

#Unit 7. System Physiology – Animal

Steroid and polypeptide hormones typically have in common ________.

#Question id: 11547

#Unit 7. System Physiology – Animal

A cluster of tumor cells that produces and secretes growth factors to induce surrounding cells to grow and divide is showing which type of cell-to-cell signaling?

#Question id: 11548

#Unit 7. System Physiology – Animal

If a portion of the pancreas is surgically removed from a rat and the rat subsequently loses its appetite, one explanation is that the removed portion contains cells that secrete a chemical signal that somehow stimulates appetite. Given this scenario, what type of chemical signaling is occurring?

#Question id: 11549

#Unit 7. System Physiology – Animal

If a biochemist discovers a new molecule, which of the following pieces of data would allow her to draw the conclusion that the molecule is a steroid hormone?

I) The molecule is lipid soluble.

II) The molecule is derived from a series of steps beginning with cholesterol.

III) The molecule acts at a target tissue some distance from where it is produced.

IV) The molecule uses a transport protein when in an aqueous solution such as blood.

#Question id: 11550

#Unit 7. System Physiology – Animal

Which of the following are similar in structure to cholesterol?

I) estradiol

II) insulin

III) glucocorticoids

IV) testosterone

V) antidiuretic hormone

#Question id: 11551

#Unit 7. System Physiology – Animal

Polypeptides can have which of the following types of effects?

I) autocrine

II) paracrine

III) endocrine