Following statements are regarding to the Surveillance mechanisms in cell cycle regulation.

A. Surveillance mechanisms known as checkpoint pathways establish dependencies among cell cycle events and ensure that the next cell cycle event does not occur prior to the completion of a preceding event.

B. In response to DNA damage, two related protein kinases, ATM and ATR, are recruited to the site of the damage, where they activate signaling pathways that lead to cell cycle arrest, repair, and under some circumstances, apoptosis.

C. The spindle assembly checkpoint pathway, which causes initiation of anaphase, utilizes Mad2 and other proteins to regulate APC/CCdc20, which targets securing and mitotic cyclins for ubiquitinylation.

D. The spindle position checkpoint pathway prevents mitotic CDK inactivation when the spindle is mispositioned. In this pathway, localized activators and inhibitors and a sensor that shuttles between them allow cells to sense spindle position.

Which of the following statement is incorrect?

TLS Online TPP Program

#Question id: 33524

#Unit 2. Cellular Organization

A. Only 1% of the human genome consists of exons.

B. The genes (exons plus introns) comprise 25% of the genome.

C. 60% of human genes are alternatively spliced.

D. Up to 80% of the alternative splices change protein sequence, so the human proteome has 50,000 to 60,000 members.

Find true and false statements

TLS Online TPP Program

#Question id: 33525

#Unit 2. Cellular Organization

The average human gene is 

TLS Online TPP Program

#Question id: 33526

#Unit 2. Cellular Organization

The number of protein-coding genes is less than the number of potential polypeptides that can result in several polypeptides from the same gene because of mechanisms 

A. alternative splicing

B. alternate promoter selection, 

C. alternate poly(A) site selection

D. Number of Introns in the gene

TLS Online TPP Program

#Question id: 33527

#Unit 2. Cellular Organization

Match the following

TLS Online TPP Program

#Question id: 33528

#Unit 2. Cellular Organization

The Y chromosome has 

TLS Online TPP Program

#Question id: 33529

#Unit 2. Cellular Organization

A. X and Y chromosomes have descended from a common, very ancient autosome pair. 

B. X and Y chromosomes have descended from different autosome. 

C. During evolution, the X chromosome has retained most of the original genes, whereas the Y chromosome has lost most of them.

D. During evolution, the X chromosome has lost most of them, whereas the Y chromosome has retained most of the original genes.

Which of the following is correct combination