TLS Online TPP Program

#Question id: 2978


The most important regulatory control that restricts cyclins to the appropriate cell cycle stage is ubiquitin mediated, proteasome-dependent protein degradation. Which of the following statement is incorrect regarding to the degradation of protein?

#Unit 2. Cellular Organization
  1. SCF and APC/C are multisubunit ubiquitin-protein ligases that belong to the RING finger family of ubiquitin protein ligases which ensure that the cell cycle engine is driven forward and that cells cannot “go backward” in the cell cycle.

  2. SCF recognizes its substrates only when they are phosphorylated.

  3. The substrate specificity of active, dephosphorylated APC/C is determined in part by its association with one of two related substrate targeting factors called Cdc20 and Cdh1.

  4. The substrates of APC/C contain recognition motifs known as destruction box which is lysine rich.

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TLS Online TPP Program

#Question id: 4553

#Unit 3. Fundamental Processes

The NtrC protein (nitrogen regulatory protein C)—stimulates transcription of the glnA gene, this protein is an activator of σ54-RNA polymerase. Which of the following given characteristics about this protein is incorrect?

TLS Online TPP Program

#Question id: 4554

#Unit 3. Fundamental Processes

In which studies have shown that phosphorylated NtrC bound at enhancers and σ54-polymerase bound at the promoter interact directly, forming a loop in the DNA between the binding sites?

TLS Online TPP Program

#Question id: 4555

#Unit 3. Fundamental Processes

The σ54-RNA polymerase binds to the glnA promoter but does not melt the DNA strands and initiate transcription until it is activated by

TLS Online TPP Program

#Question id: 4557

#Unit 3. Fundamental Processes

In eukaryotic transcription RNA polymerase II is transcribed

TLS Online TPP Program

#Question id: 4558

#Unit 3. Fundamental Processes

Classes of RNA transcribed by the three eukaryotic nuclear RNA Polymerase;

                    Polymerase

             RNA Transcribed     

A. RNA polymerase I                   

i) tRNAs, 5S rRNA, snRNA, U6, 7S RNA

B. RNA polymerase II

ii) Pre-rRNA 28S, 18SrRNA,  5.8SrRNAs

C. RNA polymerase III

iii) mRNA, snRNAs, siRNAs, miRNAs

 Match the following correct combination given above combinations;

TLS Online TPP Program

#Question id: 4559

#Unit 3. Fundamental Processes

The 5’Cap is added to the eukaryotic nascent RNAs shortly after