#Question id: 849
#Unit 1. Molecules and their Interaction Relevant to Biology
The rigidity of the peptide unit and the restricted set of allowed phi and psi angles limits the number of structures accessible to the unfolded form sufficiently to allow:-
#Question id: 850
#Unit 1. Molecules and their Interaction Relevant to Biology
The experimental inverse of protein structure prediction, has provided insights into protein folding and stability. Protein design attempts to construct an amino acid sequence that will form a structure such as a sandwich of β sheets or a bundle of α helices;
#Question id: 851
#Unit 1. Molecules and their Interaction Relevant to Biology
Methods is the Rosetta program, formulated by David Baker. To satisfy the program’s computational needs, a volunteer network of ∼100,000 computers, known as Rosetta@home, provides the 500,000 or so hours of processing time required to generate a structure;
#Question id: 852
#Unit 1. Molecules and their Interaction Relevant to Biology
.________ enzyme revealed the relation between the amino acid sequence of a protein and its conformation.
#Question id: 853
#Unit 1. Molecules and their Interaction Relevant to Biology
In the presence of a large excess of _______ the disulfides (cystines) are fully converted into sulfhydryls (cysteines).
#Question id: 854
#Unit 1. Molecules and their Interaction Relevant to Biology
Many conditions including type 2 diabetes, Alzheimer disease, Huntington disease and parkinson disease are associated with the misfolding mechanism a soluble protein that is normally secreted from the cell is secreted in the missfold state and converted into an insoluble extracellular fibre the diseases are correctly referred to as