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TLS Online TPP Program

#Question id: 3738

Functions of DNA polymerases and accessory proteins in eukaryotic DNA replication include

#Unit 3. Fundamental Processes

  1. PCNA protein, a sliding clamp unit for DNA.

  2. β- DNA polymerase, for repair of damaged DNA.

  3. RPC protein, and equivalent of SSB proteins in bacteria.

  4. All of the above

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TLS Online TPP Program

#Question id: 20625

#Unit 11. Bioinformatics

Two types of pair-wise sequence alignment of the same hypothetical protein sequence fragments are illustrated in the figure below. Vertical bars between the
sequences indicate the presence of identical amino acids. * symbols in Figure Y indicate residues not included in the alignment.

Which one of the following is correct?
TLS Online TPP Program

#Question id: 20626

#Unit 11. Bioinformatics

Match the items in Group I with Group II with reference to a database search for identifying homologs of human hemoglobin.

Group IGroup II
(P) Sensitivity(1) Measure of how many correct hits are found
(Q) 100% Sensitivity(2) Measure of how many hits found are correct
(R) Specificity(3) Measure indicating that all correct hits are found
(S) 100% Specificity(4) Measure indicating that all hits found are correct
TLS Online TPP Program

#Question id: 20628

#Unit 11. Bioinformatics

Genes or proteins that display the same activity, but have different origins and are the product of convergent evolution, are called:
TLS Online TPP Program

#Question id: 20629

#Unit 11. Bioinformatics

Match the type of BLAST programs given in Group I to the particular type of sequence search task described in Group II

Group IGroup II
1. tblastnP. A nucleotide sequence is to be used as a query to search for similar proteins against a nucleotide database
2. tblastxQ. A nucleotide sequence is to be used as a query to search against a protein database
3. blastx
4. blastn
TLS Online TPP Program

#Question id: 20630

#Unit 11. Bioinformatics

In a multiple sequence alignment of homologous protein sequences, a region of multiple insertions and deletions indicates the presence of:
TLS Online TPP Program

#Question id: 20633

#Unit 11. Bioinformatics

A novel protein from a deep sea archaebacterium was identified and sequenced. The sequence is expected to be widely divergent from known sequences. Which scoring
matrix will produce the most appropriate alignment in a search for homologs in the NCBI database?