Choose the correct statement of the following

a. In general, high acetyl-CoA or citrate are present, or when a high proportion of the cell’s adenylate is in the form of ATP, gluconeogenesis is favored.

b. When the level of AMP increases, it promotes glycolysis by stimulating PFK-1 by inhibiting FBPase-1

c. Phosphorylation of fructose 6-phosphate, catalysed by phosphofructokinase-2 (PFK-2)

d. Glucagon increases the cellular level of fructose 2,6 bisphosphate, stimulating glycolysis and inhibiting gluconeogenesis.

#Question id: 1399

#Unit 4. Cell Communication and Cell Signaling

Loss-of-function mutations in which of the following genes typifies colorectal carcinomas?

a. myc              b. K-ras                       c. p53              d. APC

#Question id: 1400

#Unit 4. Cell Communication and Cell Signaling

Which property is shared by malignant tumor cells and transformed cells in culture?

a. reduced growth factor requirement                        b. attachment-dependent growth

c. loss of actin microfilaments                                    d. altered morphology

#Question id: 1401

#Unit 4. Cell Communication and Cell Signaling

Which of the following are proto-oncogenes?

a. fos               b. myc             c. p53              d. ras               e. Rb

#Question id: 1402

#Unit 4. Cell Communication and Cell Signaling

Which of the following oncoproteins possess(es) protein kinase activity?

#Question id: 1403

#Unit 4. Cell Communication and Cell Signaling

Tumor-suppressor genes encode proteins with which of the following functions?

a. growth-promoting               b. growth-arresting                  c. pro-apoptotic

d. anti-apoptotic                      e. DNA repair

#Question id: 1404

#Unit 4. Cell Communication and Cell Signaling

Which of the following are transcription factors?