#Question id: 4460
#Unit 3. Fundamental Processes
During initial transcription, the active center of RNA polymerase is translocated forward relative to the DNA template and synthesizes short transcripts before aborting, then repeats this cycle until it escapes the promoter. Three models have been proposed to account for this;
i. Polymerase moves along the DNA.
ii. The front part of the enzyme moves along the DNA, but because of a flexible region within the enzyme, the back part of the enzyme can remain stationary at the promoter.
iii. The enzyme remains stationary and pulls the DNA into itself.
#Question id: 5259
#Unit 8. Inheritance Biology
Genetic variation in bacterial populations cannot result from
#Question id: 1999
#Unit 4. Cell Communication and Cell Signaling
Which of the following would be most beneficial in treating an individual who has been bitten by a poisonous snake that has a fast-acting toxin?
#Question id: 24592
#Unit 2. Cellular Organization
#Question id: 4484
#Unit 3. Fundamental Processes
Match General Transcription Factors with their functions;
i. TAFs |
A. Appears to regulate the binding of TBP to DNA. It does this using an inhibitory flap that binds to the DNA-binding surface of TBP, another example of molecular mimicry. This flap must be displaced for TBP to bind TATA. |
ii. TFIIB |
B. Insert into the RNA-exit channel and active center cleft of Pol II in a manner analogous to the sigma region 3/4 linker in the bacterial case. |
iii. TFIIH |
C. As an ATP-driven translocator of double-stranded DNA. |
iv. TFIIF |
D. This two-subunit (in humans) factor associates with Pol II and is recruited to the promoter together with that enzyme. |