Hutchinsonian niche is proposed by G. Evelyn Hutchinson, that basically based on

#Question id: 21274

#Unit 12. Applied Biology

#Question id: 33468

#Unit 1. Molecules and their Interaction Relevant to Biology

#Question id: 1521

#Unit 4. Cell Communication and Cell Signaling

we examine how the deregulation of growth-promoting and growth-inhibiting signaling pathways contributes to tumorigenesis. Mutations-

A. A mutation that alters a single amino acid (valine to glutamine) in the transmembrane region of the HER2 receptor

B. A deletion that causes loss of the extracellular ligand-binding domain in the EGF receptor Results-

i. dimerization of the receptor, even in the absence of the normal EGF-related ligand, transforming it into the oncoprotein, a constitutively active kinase

ii. to constitutive activation of the kinase activity of the resulting oncoprotein

iii. no dimerization, even in the presence of the normal EGF-related ligand, repression of kinase activity

which of the following results are displayed after these mutations?

#Question id: 12117

#Unit 10. Ecological Principles

#Question id: 15291

#Unit 5. Developmental Biology