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TLS Online TPP Program

#Question id: 27080

Choose the correct statement about Vander-wall interaction  
1. Van der Waals potential (Evdw) is the sum of all interactions over all atoms
2. Van der Waals potential (Evdw)  is calculated by
3. This type of interaction is often called a 6–12 interaction, or the Leonard Jones potential.
4. Van der Waals forces are extremely weak, especially when compared with other forces influencing protein conformation

#Unit 1. Molecules and their Interaction Relevant to Biology
  1.  1 only   
  2.  2 & 3 
  3.  3 & 4  
  4. 1, 2, 3, & 4
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TLS Online TPP Program

#Question id: 2831

#Unit 2. Cellular Organization

Specific DNA control elements in promoters can

a. interact with general transcription factors.

b. interact with repressor proteins.                 

c. interact with activator proteins.

d. remain unavailable because of condensed chromatin. 
TLS Online TPP Program

#Question id: 2832

#Unit 2. Cellular Organization

Reporter genes are used to

a. express enzymes that are not easily assayed in cell extracts.

b. express enzymes that are easily assayed in cell extracts.

c. characterize DNA control elements.                     

d. characterize reporter plasmids.
TLS Online TPP Program

#Question id: 2835

#Unit 2. Cellular Organization

An enhancer

a. can be located upstream of a promoter.

b. can be located downstream of a promoter.

c. can be located a variable distance from the promoter.

d. is always located within 1 kb of the promoter.

e. can be cell-type-specific.
TLS Online TPP Program

#Question id: 2836

#Unit 2. Cellular Organization

The fact that a specific protein leaves a “footprint” on a DNA molecule is indicative of
a. a lack of interaction between the specific protein and DNA.
b. protection from DNAse by the specific protein.
c. binding of the specific protein to all types of DNA.
d. binding of the specific protein to a specific sequence of DNA.
TLS Online TPP Program

#Question id: 2837

#Unit 2. Cellular Organization

The C-terminal activation domain of transcriptional activators is capable of
a. binding to DNA.                 
b. stimulating transcription.
c. interaction with other transcriptional machinery.
d. functioning in a fusion with a DNA-binding domain from an unrelated transcriptional activator.
TLS Online TPP Program

#Question id: 2838

#Unit 2. Cellular Organization

You want to study the potential interaction between nucleosome-bound DNA and a specific histone deacetylase. You decide to perform an electrophoretic mobility shift assay (EMSA). You use a 32P end-labelled, linear template DNA that contains two nucleosome positioning sites. You assemble two nucleosomes on the DNA template before incubation with and without the histone deacetylase. For some reactions, you use unmodified nucleosomes. For other reactions, you use nucleosomes that are methylated at lysine 36 of the histone protein H3.

A. The histone deacetylase binds nucleosome bound-DNA in lanes 1, 2, 3, and 4.

B. The histone deacetylase binds nucleosome bound-DNA in lanes 3& 4.

C. The histone deacetylase seems to recognize methylated nucleosomes at lysine 36 of histone H3 in lane 1, 2 & 3 better than unmethylated nucleosomes in lane 4 &5

D. The histone deacetylase seems to recognize methylated nucleosomes at lysine 36 of histone H3 in lane 1 & 2 better than unmethylated nucleosomes in lane 3 &4