Tay-Sachs disease belongs to the family of lysosomal storage diseases; it is an autosomal recessive neurodegenerative disorder caused by deficiency of the lysosomal enzyme hexosaminidase. The inability to degrade sphingolipids results in the deposition of these lipids in the cells that causes severe mental retardation and death in childhood. The most common mutation in Tay-Sachs disease patients is a 4-base pair insertion in exon 11 of the 14 exons of the hexosaminidase gene. What could be the most likely consequence of this mutation?

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#Question id: 31409

#Unit 2. Cellular Organization

Mutation in golgi-resident enzyme, Phosphodiesterase inhibit which of the following process during Trafficking of soluble lysosomal enzymes?

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#Question id: 14145

#Unit 6. System Physiology – Plant

Which of the following spot is inhibted by Antimycin A

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#Question id: 23702

#Unit 13. Methods in Biology

The major advantage of using artificial chromosomes such as YACs and BACs for cloning genes is that

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#Question id: 12320

#Unit 10. Ecological Principles

Animals that help other animals of the same species are expected to

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#Question id: 33284

#Unit 2. Cellular Organization

Assembly of the contractile ring results in part from the local formation of new actin filaments, which depends on: