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TLS Online TPP Program

#Question id: 4118

If the 5’ splice site sequence changed from 5’- GUAAGU-3’ to 5’-GUAUGU-3’, predict the effect of the sequence change on U1 binding and U6 snRNP binding in an in vitro protein– RNA binding assay.

#Unit 3. Fundamental Processes

  1. The mutation will not change binding of U1 and on other hand this will likely enhance binding of the U6 snRNP with the 5’ splice site

  2. The mutation will likely cause an increase in binding of U1 and on other hand this will not change binding of the U6 snRNP with the 5’ splice site

  3. The mutation will likely cause a decrease in binding of U1 and on other hand this will likely enhance binding of the U6 snRNP with the 5’ splice site

  4. The mutation will likely cause a decrease in binding of U1 and on other hand this will not change binding of the U6 snRNP with the 5’ splice site

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TLS Online TPP Program

#Question id: 12952

#Unit 7. System Physiology – Animal

Which of the following changes would tend to increase Ca2+ reabsorption in the renal tubule?
TLS Online TPP Program

#Question id: 12953

#Unit 7. System Physiology – Animal

 Which of the following diuretics inhibits Na+-2Cl−-K+ co-transport in the loop of Henle as its primary action?
TLS Online TPP Program

#Question id: 12954

#Unit 7. System Physiology – Animal

A 55-year-old male patient with hypertension has had his blood pressure reasonably well controlled by administration of a thiazide diuretic. During his last visit (6 months ago) his blood pressure was 130/75 mm Hg and his serum creatinine was 1 mg/100 ml. He has been exercising regularly for the past 2 years, but recently has complained of knee pain and began taking large amounts of a nonsteroidal anti-inflammatory drug. When he arrives at your office, his blood pressure is 155/85 and his serum creatinine is now 2.5 mg/100 ml. Which of the following best explains his increased serum creatinine?
TLS Online TPP Program

#Question id: 12955

#Unit 7. System Physiology – Animal

Which of the following would tend to decrease GFR by more than 10% in a normal kidney?
TLS Online TPP Program

#Question id: 12956

#Unit 10. Ecological Principles

For  nearly 200  years, biogeographers have  noted that  the  tropics  have  more terrestrial species than  temperate regions. Which of the following is NOT a plausible explanation for this pattern?
TLS Online TPP Program

#Question id: 12957

#Unit 10. Ecological Principles

Dichlorodiphenyltrichloroethane is related to the phenomenon of: