TLS Online TPP Program

#Question id: 4165


Which is true about proofreading activity during the synthesis of aminoacyl-tRNAs?

#Unit 3. Fundamental Processes
  1. Proofreading is accomplished as an amino acid enters the active site of the enzyme. Incorrect amino acids are rejected before any reaction occurs.

  2. Proofreading occurs just after aminoacyl-adenylate formation.

  3. A separate cytosolic proofreading enzyme catalyzes the hydrolysis of incorrect aminoacyl-tRNAs.

  4. No proofreading activity is necessary due to the high level of specificity of all aminoacyl-tRNA synthetases.