One mechanism that contributes to the fidelity of codon recognition involves the 16S rRNA other than initiation. Which of the following statements are correct in this phenomenon?

A. Codon recognition involves two adjacent uracil residues in the 16S rRNA component

B. The adjacent residues in the 16S rRNA do not discriminate between G:C or A:U base pairs and recognize either as correct

C. Even a single mismatch in the codon–anticodon base pairing alters the position of EF-Tu, reducing its ability to interact with the factor-binding center 16s rRNA, leads to a dramatic reduction in EF-Tu GTPase activity

D. Pyrophasphatic editing is key mechanism to ensure fidelity

TLS Online TPP Program

#Question id: 15341

#Unit 4. Cell Communication and Cell Signaling

Formation of pre B-cell  describing__

A. Surrogate light chain formation 

B. On these surface present IgM

C. Heavy chain had been formed

D. DJ H chain recombination

TLS Online TPP Program

#Question id: 15342

#Unit 4. Cell Communication and Cell Signaling

The heavy chain is then expressed on the cell surface in combination with the surrogate light chain, which is made up of_______________, together they form the pre-B-cell receptor,

TLS Online TPP Program

#Question id: 15360

#Unit 4. Cell Communication and Cell Signaling

The cytochrome P450 constitute a superfamily of heme-containing enzymes that occur in nearly all living organisms, from bacteria to mammals, These monooxygenases, which in animals are embedded in the endoplasmic reticulum membrane, catalyze reactions of the sort

                  RH + O₂ + 2 H⁺ + 2e⁻ → ROH + H₂O 

The electrons (e−) are supplied by NADPH, which passes them to cytochrome P450’s heme prosthetic group via the intermediacy of the enzyme NADPH P450 reductase. Here RH represents a wide variety of usually lipophilic compounds for which the different cytochromes P450 are specific. They include

a. polycyclic aromatic hydrocarbons 

b. polycyclic biphenyls

c. frequently carcinogenic compounds that are present in tobacco smoke, broiled meats, and other pyrolysis products

d. which were widely used in electrical insulators and as plasticizers and are also carcinogenic.

TLS Online TPP Program

#Question id: 15361

#Unit 4. Cell Communication and Cell Signaling

The chemical benzo(a)pyrene, found in cigarette smoke as well as in coal tar, undergoes metabolic activation in the lungs to form a potent mutagen that mainly, causes conversion of guanine (G) to thymine (T) bases, a transversion mutation, When applied to cultured bronchial epithelial cells, activated benzo(a)pyrene induces many mutations, including inactivating mutations of the p53 gene, at codon number______

TLS Online TPP Program

#Question id: 15362

#Unit 4. Cell Communication and Cell Signaling

Aflatoxin a fungal metabolite found in moldy grains, induces

TLS Online TPP Program

#Question id: 15363

#Unit 4. Cell Communication and Cell Signaling

Epithelial-to-mesenchymal transition (EMT) is thought to play a crucial role during the process of metastasis in some cancers, Snail and Twist are the two transcription factors, function as EXCEPT