The activators bind—and the enhanceosome forms—in a highly cooperative manner, ensuring that all three activators must be present. The following are three ways the regulators might be binding cooperatively:

I- Through direct protein–protein interactions between them

II- By changes in the DNA caused by binding of one protein helping binding of another;

III- By the fact that the activators all interact simultaneously with the coactivator.

TLS Online TPP Program

#Question id: 34091

#Unit 3. Fundamental Processes

DnaA has intrinsic ATPase activity that hydrolyzes ATP to ADP and thus inactivates itself when the initiation stage ends. This ATPase activity is stimulated by 

A. Membrane phospholipids which helps in ATP hydrolysis

B. dsDNA which is substrate for DnaA

C. Membrane phospholipids which provide ATP in exchange of ADP

D. ssDNA which is created in first step

Which of the following is correct combination

TLS Online TPP Program

#Question id: 34092

#Unit 3. Fundamental Processes

A. SeqA binds to hemimethylated DNA and is required for delaying rereplication.

B. As the origins are hemimethylated they bind to the cell membrane and may be unavailable to methylases.

C. The dat locus contains DnaA-binding sites that titrate availability of DnaA protein.

D. Hda protein is recruited to the replication origin to convert DnaA-ATP to DnaA-ADP.

Choose true and false

TLS Online TPP Program

#Question id: 34093

#Unit 3. Fundamental Processes

Quite large regions of the eukaryotic chromosome can be characterized as “early replicating” or “late replicating,”. These site can be recognised by

TLS Online TPP Program

#Question id: 34094

#Unit 3. Fundamental Processes

The rate of eukaryotic replication is 2000 bp/min and replicon size is 40kb. How much time it will take replicate entire human chromosome

TLS Online TPP Program

#Question id: 34095

#Unit 3. Fundamental Processes

The origin recognition complex (ORC) is a highly conserved complex found in all eukaryotes. It is composed of six proteins and it binds to 

TLS Online TPP Program

#Question id: 34096

#Unit 3. Fundamental Processes

A eukaryotic genome is divided into multiple replicons, and the origin in each replicon is activated once and only once in a single division cycle. It is due to